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Evaluation of the toxicological effect of indomethacin on internal organs on experimental rats

Project proposal

Indomethacin is a non-steroidal anti-inflammatory drug (NSAID) that is widely used to treat pain and inflammation. However, diclofenac can also cause toxicity to internal organs, such as the liver and kidneys. This study proposes to investigate Indomethacin's toxic effect on rats' internal organs. The study will assess the extent of Indomethacin -induced toxicity on different organs, such as the brain, eye, lung, heart, liver, stomach, pancreas, spleen, kidney, bladder, reproductive system, bone, skin, and muscle. The study will involve administering a toxic dose of indomethacin to groups of rats and monitoring their organ morphology changes. Histopathological analysis of organ tissues will also be conducted to observe for any morphological changes or abnormalities. Additionally, the study will investigate indomethacin -induced dysfunction by CT. The findings of this study will contribute to a better understanding of the harmful effects of indomethacin on internal organs. This knowledge can inform more informed decisions regarding the safe use of indomethacin and the development of possible interventions to mitigate toxicity. Furthermore, the investigation of indomethacin -induced toxicity mechanisms may enable the identification of potential biomarkers that can serve as early indicators of organ damage. This proposed study will be conducted following ethical guidelines and protocols established by the appropriate regulatory bodies.
Review title: 

Review on indomethacin toxicities in different organs

Article title: 


Pathology gallery

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Pathology report

Radiology gallery

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Radiology report
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