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Clinical Toxicology

Adverse outcome pathway

Amr Adel Elnashar

1 Minute reading

An adverse outcome pathway (AOP) is a model that shows how biological events lead to harmful effects. It is important for risk assessment because it helps us understand how chemicals and other stressors can cause harm at different levels of biological organization, from molecules to cells to organs to whole organisms.

AOPs are linear chains of cause-and-effect events, starting with a molecular initiating event (MIE) and ending with an adverse outcome (AO). Each event in the chain is called a key event (KE), and the relationships between the events are called key event relationships (KERs).

AOPs are important because they allow us to use mechanistic toxicological data to assess chemical risk. This means that we can understand how chemicals cause harm at a biological level, even if we don't have all of the data we need to conduct traditional toxicological tests.

AOPs are also being used in other fields, such as climate science. For example, AOPs are being used to understand how climate change can impact human health.

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Experimental toxicology

Experimental toxicology, the basic issue part 2

Most industrial chemical exposures occur through the skin or by inhalation. However, these risks can be limited and controlled in the workplace.

Amr Adel Elnashar

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